We have an iPhone, an iPod Touch an older 60GB iPod and Apple TV. All synced to the iTunes on my Mac Mini (old power PC G4 processor) and runninc OS X 10.4.2

Other than that, my answers are the same as Jonathan's. Music and library in standard place. QT 10.4.1.

I have a Airport Express with Airtunes upstairs so I do use the option to play music through that as well as the speakers attached to the Mac and the Apple TV. The upstairs part is why Remote Buddy seems the perfect toy for me.

If my girlfriend was not coming home any minute, I would try downgrading to 7.5.... maybe later in the week!