When you press a button on the Logitech Harmony Smart Control remote control, the button press is sent over RF to Logitech's Harmony Hub, which in turn can forward it to your Mac via Bluetooth.
A direct Bluetooth connection between the Logitech Harmony Smart Control remote control and your Mac is not possible.
Configuring Harmony Smart Control for Remote Buddy 2Knowledge Base
Resetting Bluetooth How do I set up the Harmony Hub and connect it to your app on my Mac? Nothing happens when I press a button on the Harmony Hub remote. When the Harmony Hub connects to my Mac, I'm asked for a PIN.
RF (Remote to Hub),|
Bluetooth (Hub to Mac)
|Battery||CR-2032 coin cell|